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Conessine, Tocris Bioscience™

Catalog No. 240950
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Quantity:
50 mg
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This item is not returnable. View return policy

Description

Potent and selective H3 receptor antagonist

Potent and selective histamine H3 receptor antagonist (pKi values are 7.61 and 8.27 at rat and human H3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC50 = 1.04 μM). Also has high affinity for α2C adrenoceptors (pKi = 7.98).

Chemical Identifiers

CAS 546-06-5
Molecular Formula C24H40N2
Molecular Weight (g/mol) 356.60
MDL Number MFCD00016752
InChI Key GPLGAQQQNWMVMM-MYAJQUOBSA-N
Synonym conessine, roquessine, neriine, conessinum, wrightine, conessin, unii-ez38j9bbdf, ez38j9bbdf, konessin, conessine inn
PubChem CID 441082
ChEBI CHEBI:27965
IUPAC Name (1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethyl-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-16-amine
SMILES C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C

Specifications

Quantity 50 mg
Formula Weight 356.59
Percent Purity >98%
Chemical Name or Material Conessine

Safety and Handling

Recommended Storage Store at Room Temperature
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