Medchemexpress LLC Copanlisib dihydrochloride | 1402152-13-9 | C23H30Cl2N8O4 | 50 MG

Supplier:  Medchemexpress LLC HY15346A50MG

Copanlisib dihydrochloride is a potent, selective, and ATP-competitive pan-class I PI3K inhibitor. It exhibits IC50 values of 0.5 nM for PI3Kα, 0.7 nM for PI3Kδ, 3.7 nM for PI3Kβ, and 6.4 nM for PI3Kγ. This compound demonstrates superior antitumor activity and shows over 2,000-fold selectivity against other lipid and protein kinases, with the exception of mTOR.

• Induces apoptosis in a subset of tumor cell lines resistant to certain treatments.
• Shows complete inhibition of PI3K-mediated AKT phosphorylation in ELT3 cells at 5 nM.
• Potently inhibits cell proliferation in various human tumor cell lines, particularly those with PIK3CA-activating mutations or HER2-positive.
• Significantly increases caspase-9 activities and levels of phosphorylated p53 at Ser15 and cleaved PARP in BT20 breast cancer cells.
• Demonstrates robust antitumor activity in rat KPL4 tumor xenograft models, with high tumor growth inhibition rates.

Catalog No. 50-003-73721