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Cayman Chemical CoptIsInchlorIde 100mg
Supplier: Cayman Chemical 28424100 MG
An isoquinoline alkaloid; scavenges ROS in isolated kidney mitochondria in a DCFH-DA assay (IC50 = 48.93 μM); inhibits AChE and BChE but not BACE1 in cell-free enzyme assays (IC50s = 0.8, 5.81, and >100 μM, respectively); inhibits IDO in vitro (IC50 = 6.3 μM); inhibits OCT1, OCT2, and OCT3 in MDCK cells (IC50s = 0.931, 2.27, and 2.27 μM, respectively, for the human transporters); inhibits proliferation of A549, H460, and H2170 human lung cancer cells (IC50s = 18.09, 29.5, and 21.6 μM, respectively); decreases total serum cholesterol, triglyceride, and LDL-cholesterol levels and increases serum HDL-cholesterol levels in Syrian golden hamsters fed a high-fat and high-cholesterol diet at 70.05 mg/kg
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