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AdipoGen Cordycepin
Supplier: AdipoGen CDXC0339M100
Chemical. CAS 73-03-0. Formula C10H13N5O3. MW 251.24. Synthetic. Cordycepin is a nucleoside adenosine analog antibiotic that acts as a polyadenylation inhibitor when converted to 3’-deoxyadenosine triphosphate 3-dATP, which inhibits ATP-dependent DNA and RNA synthesis. Cordycepin has a broad spectrum of biological activities, including anticancer, anti-proliferative, pro-apoptotic, anti-inflammatory and antifungal effects. It was shown to modulate autophagy and NLRP3 inflammasome. Cordycepin has been shown to reduce polyA tail length in mRNA, to activate AMPK kinase, leading to a reduction in mTOR signalling, downregulate ERK/Akt/PI3K/GSK-3beta/beta-catenin signaling pathways. Also useful for the study of messenger RNA transcription.
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