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Cayman Chemical CotadutIdeacetate 10mg
Supplier: Cayman Chemical 4071410 MG
A synthetic peptide and peptide dual agonist of GLP-1R and GCGR; increases cAMP accumulation in CHO cells overexpressing recombinant human GLP-1R or GCGR (EC50s = 6.9 and 10.2 pM, respectively); reduces food intake and fat mass, as well as improves glucose tolerance in DIO mice at 10 nmol/kg; reduces food intake and body weight in wild-type, but not Glp1r knockout mice; reduces the hepatic lipid percentage in both wild-type and Glp1r knockout mice; reduces total hepatic triglycerides, diglycerides, cholesterol, and free fatty acids, as well as reduces hepatic inflammation and fibrosis, in an ob/ob mouse model of NASH induced by a high-trans fat, high-fructose, and high-cholesterol diet at 10 nmol/kg
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