(-)-Cotinine, 98%

Description

CAS: 486-56-6 | C10H12N2O | 176.219 g/mol

(-)-Cotinine is used to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature is 2 - 8°C.

Specifications

Chemical Identifiers

• CAS: 486-56-6
• Molecular Formula: C10H12N2O
• Molecular Weight (g/mol): 176.219
• MDL Number: MFCD00077696
• InChI Key: UIKROCXWUNQSPJ-VIFPVBQESA-N
• Synonym: cotinine, --cotinine, cotinina, cotininum, cotinine-, s-cotinine, s---cotinine, unii-k5161x06ll, s-1-methyl-5-3-pyridinyl-2-pyrrolidinone, 2-pyrrolidinone, 1-methyl-5-3-pyridinyl-, 5s
• PubChem CID: 854019
• ChEBI: CHEBI:68641
• IUPAC Name: (5S)-1-methyl-5-pyridin-3-ylpyrrolidin-2-one
• SMILES: CN1C(CCC1=O)C2=CN=CC=C2

• Melting Point: 34°C to 39°C
• Boiling Point: 145°C to 147°C (3 mmHg)
• Flash Point: >110°C (230°F)
• Quantity: 250 mg
• Beilstein: 83099
• Merck Index: 14,2553
• Solubility Information: Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM),ethanol (50mg/ml,yielding a clear,faint yellow to yellow solution),methanol and chloroform.
• Optical Rotation: −20° (c=1 in Ethanol)
• Formula Weight: 176.22
• Percent Purity: 98%
• Chemical Name or Material: (-)-Cotinine

Safety and Handling

Hazard Category	H302-H315-H319-H335
Hazard Statement	GHS H Statement H302-H315-H319-H335 Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber	207-634-9
RTECSNumber	GN1925500
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only