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Cayman Chemical CP 154 526hydrochlorIde 1mg
Supplier: Cayman Chemical 207321 MG
An antagonist of CRF1 (Ki = 2.7 nM); selective for CRF1 over CRF2 (Ki = >10 μM); inhibits CRF-induced increases in ACTH levels in rat plasma (ID50 = 10 mg/kg); increases the time spent in the open arms of the elevated plus maze in rats at 1 mg/kg; decreases immobility time in the forced swim test in a rat model of depressive-like behavior at 10 mg/kg, twice per day for 14 days; decreases stress-induced reinstatement of cocaine or heroin self-administration in cocaine- and heroin-trained rats, respectively, at 15 and 30 mg/kg
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