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Medchemexpress LLC CP 339818 (hydrochloride) | 478341-55-8 | 99.6% | 340.89 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY10857450MG

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CP 339818 hydrochloride is a non-peptide blocker of Kv1.3 (IC50 = 200 nM) and Kv1.4 channels. It also inhibits HCN channels with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl-), respectively. The compound exhibits significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. It can be utilized for studying the physiological functions of HCN and Kv channels.

  • Non-peptide Kv1.3 and Kv1.4 channel blocker.
  • Inhibits HCN channels (HCN1 and HCN4).
  • Selectively blocks Kv1.3, inhibiting human T cell activation.
  • Useful for studying physiological functions of HCN and Kv channels.
  • Suppresses human T cell activation.
  • Effectively blocks remaining outward potassium current in Kv2.1⁻/⁻ β cells.
  • Inhibitory effect on HCN1 and HCN4 is weakened in low-concentration Cl- internal solution and is voltage-dependent.

Catalog No. 50-003-45247


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