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Medchemexpress LLC CP-466722 | 1080622-86-1 | 99.7% | 349.35 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY11002100MG

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CP-466722 is a rapidly reversible inhibitor of ATM (IC50 of 0.41 μM). It does not affect PI3K or related PIKK family members. This compound is for research use only. It effectively inhibits IR-induced ATM kinase activity, with this inhibition being rapid and completely reversible.

  • Inhibits p53 induction and ATM-dependent phosphorylation in mouse cells.
  • Does not inhibit ATR activity.
  • Disrupts ATM-dependent cell cycle checkpoints.
  • Completely inhibits ATM-dependent phosphorylation in MCF7 cells at 1 μM.
  • Reduces pKAP1 phosphorylation in MCF7 cells (IC50 of 0.41 μM at 10 μM).
  • Inhibits both pATM and pKAP1 signals.
  • Inhibits proliferation of SKBr-3 cancer cells more strongly than MCF-7.
  • Slightly increases proportions of MCF-7 and SKBr-3 cells in G1 phase after 48 hours.

Catalog No. 50-003-44163


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