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Apexbio Technology LLC CP-673451 343787-29-1 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC B21735.1

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CP-673451 (CAS 343787-29-1) is an ATP-competitive inhibitor with specificity for platelet-derived growth factor receptors (PDGFR- / ) It exhibits inhibitory potency with IC50 values of 10 nM for PDGFR- and 1 nM for PDGFR- while demonstrating significantly less inhibition toward kinases such as VEGFR-1 VEGFR-2 Lck TIE-2 and EGFR In cellular assays CP-673451 effectively inhibits PDGFR- phosphorylation in PAE- cells (IC50 6 4 nM) and reduces c-kit activity in H526 cells at micromolar range Its anticancer efficacy has been established by suppressing tumor growth and vascularization in xenograft models indicating its potential utility in cancer research and angiogenesis studies

Catalog No. 50-000-62180


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