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Cayman Chemical CP 99 994hydrochlorIde 10mg
Supplier: Cayman Chemical 2766910 MG
A nonpeptide NK1 receptor antagonist (Ki = 0.25 nM in a radioligand binding assay); selective for NK1 over NK2 and NK3 receptors (Kis = >10 μM for both); inhibits excitation of guinea pig locus coeruleus cells induced by substance P in vitro (IC50 = 25 nM); inhibits increases in horizontal locomotor activity induced by [Sar9,Met(O2)11]-substance P in guinea pigs (ID50 = 0.59 mg/kg); inhibits aerosolized capsaicin-induced plasma extravasation in guinea pig lung (ID50 = 4 mg/kg); exhibits anti-emetic effects in ferret models of emesis induced by copper sulfate, loperamide, or cisplatin at 0.3 and 1 mg/kg
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