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Medchemexpress LLC CPD-1224 | 2891620-68-9 | C43H47ClN8O7S | 100 MG
Supplier: Medchemexpress LLC HY153386100MG
CPD-1224 is an orally effective ALK inhibitor derived from an ALK inhibitor that connects to the cereblon ligand. It targets the EML4-ALK oncogenic fusion protein, leading to the degradation of both ALK and its mutant forms L1196M/G1202R. This compound has the potential to slow down tumor growth and is for research use only.
- Enhances kinase binding selectivity and exhibits good degradation selectivity
- Shows antiproliferative activity against mouse Ba/F3 cells
- Demonstrates oral bioavailability of 28% in mice (10 mg/kg, oral)
- Inhibits tumor growth in mice by reducing total ALK and phosphorylated ALK levels
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