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Apexbio Technology LLC CPI-455 HCl 2095432-28-1 25mg
Supplier: Apexbio Technology LLC B781125
CPI-455 HCl (CAS 2095432-28-1) is a potent inhibitor of the KDM5 family of histone demethylases which regulate demethylation of histone H3 lysine 4 (H3K4) CPI-455 exhibits an IC50 of 10 nM for KDM5A in enzymatic assays and displays comparable inhibitory activity against KDM5B and KDM5C but markedly reduced potency for KDM4C and KDM7B and negligible activity towards other KDM family members In vitro CPI-455 treatment leads to a dose-dependent increase in global H3K4me3 levels in HeLa cells with rapid reversal upon compound removal This compound is used in research to probe the role of KDM5-mediated histone modifications and the survival mechanisms of drug-tolerant cancer cell populations
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