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Apexbio Technology LLC CPI-613 95809-78-2 10mg
Supplier: Apexbio Technology LLC A433310
CPI-613 (CAS 95809-78-2) is an anticancer small molecule targeting mitochondrial energy metabolism It acts by inhibiting the pyruvate dehydrogenase (PDH) complex and -ketoglutarate dehydrogenase ( -KGDH) enzyme complexes involved in mitochondrial carbon metabolism that rely on lipoate cofactors CPI-613 a lipoate derivative disrupts mitochondrial bioenergetics decreasing ATP levels and mitochondrial membrane potential in cancer cells In vitro CPI-613 suppresses proliferation and induces apoptosis in acute myeloid leukemia (AML) cell lines such as HL60 Jurkat and K562 (IC50 16 4 M 13 4 M 12 2 M respectively) In vivo studies demonstrate tumor growth inhibition in mouse xenograft models of human non-small cell lung carcinoma (H460) and pancreatic tumor (BxPC-3) highlighting its research potential in oncology
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