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Cayman Chemical cPP1-7 NPY19-23 Ala31 AIb325mg
Supplier: Cayman Chemical 367185 MG
An agonist of NPY receptor Y5; inhibits forskolin-induced cAMP production in HEK293 cells expressing the Y5 receptor (EC50 = 17 nM); selectively binds to Y5 (IC50 = 0.24 nM in HEK293 cells expressing the human receptor) over Y1, Y2, and Y4 (IC50s = 530, >500, and 51 nM, respectively, in BHK-21 cells expressing the human receptors); increases VEGF levels, as well as endothelial branch length and branch points, in 4T1 cells in a concentration-dependent manner; induces relaxation of vasopressin-precontracted rat mesenteric arteries at 1 µM; increases food intake in rats at 0.2 and 2 nmol/animal, i.c.v.
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