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Apexbio Technology LLC Crenolanib (CP-868596)(Synonyms: CP-868596, Crenolanib besylate, AR-868596, PDGFR inhibitor CP-868596, PDGFR-beta inhibitor CP-868596), 10mM (in 1mL DMSO), CAS: 670220-88-9.
Supplier: Apexbio Technology LLC A83075.1
Crenolanib (CP-868596 CAS 670220-88-9) is a selective inhibitor targeting receptor tyrosine kinases PDGFR PDGFR and FLT3 exhibiting Kd values of 3 2 nM 2 1 nM and 0 74 nM respectively It notably suppresses the FLT3 autophosphorylation and proliferation mediated via PDGFR mutations that confer resistance to imatinib such as D842V (IC50 10 nM) but does not inhibit the V561D mutant Additionally crenolanib reduces kinase activity of the FIP1L1-PDGFRA fusion protein (IC50 1 nM) and proliferation in EOL-1 cells It serves as a research tool for kinase-driven malignancies particularly those resistant to other kinase inhibitors
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