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Medchemexpress LLC Crizotinib hydrochloride | 1415560-69-8 | 99.7% | C21H23Cl3FN5O | 100 MG
SDP

Catalog No. 5000357711
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Crizotinib hydrochloride is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor. It also acts as a ROS proto-oncogene 1 (ROS1) inhibitor, demonstrating effective tumor growth inhibition. In cell-based assays, it inhibits tyrosine phosphorylation of NPM-ALK with an IC50 of 24 nM and tyrosine phosphorylation of c-Met with an IC50 of 11 nM.

  • Inhibits ALK with an IC50 of 20 nM
  • Inhibits c-Met with an IC50 of 8 nM
  • Potently prevents cell proliferation, leading to G(1)-S-phase cell cycle arrest and apoptosis induction in ALK-positive ALCL cells
  • Causes marked regression of large established tumors in GTL-16 model
  • Significantly reduces CD31-positive endothelial cells in GTL-16 tumors

Catalog No. 50-003-57711 Supplier Medchemexpress LLC Supplier No. HY50878A100MG
May include imposed supplier surcharges.
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Crizotinib hydrochloride is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor. It also acts as a ROS proto-oncogene 1 (ROS1) inhibitor, demonstrating effective tumor growth inhibition. In cell-based assays, it inhibits tyrosine phosphorylation of NPM-ALK with an IC50 of 24 nM and tyrosine phosphorylation of c-Met with an IC50 of 11 nM.

  • Inhibits ALK with an IC50 of 20 nM
  • Inhibits c-Met with an IC50 of 8 nM
  • Potently prevents cell proliferation, leading to G(1)-S-phase cell cycle arrest and apoptosis induction in ALK-positive ALCL cells
  • Causes marked regression of large established tumors in GTL-16 model
  • Significantly reduces CD31-positive endothelial cells in GTL-16 tumors

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