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Medchemexpress LLC Crizotinib hydrochloride | 1415560-69-8 | 99.7% | C21H23Cl3FN5O | 200 MG
Supplier: Medchemexpress LLC HY50878A200MG
Crizotinib hydrochloride is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor. It also acts as a ROS proto-oncogene 1 (ROS1) inhibitor, demonstrating effective tumor growth inhibition.
- Inhibits tyrosine phosphorylation of NPM-ALK and c-Met in cell-based assays
- Potently prevents cell proliferation by inducing G(1)-S-phase cell cycle arrest and apoptosis
- Causes marked regression of large established tumors in preclinical models
- Demonstrates a significant dose-dependent reduction of CD31-positive endothelial cells
- Leads to marked inhibition of phosphorylated c-Met, Akt, Erk, PLCλ1, and STAT5 levels
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