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Cayman Chemical Cryolys EvolutIon EXended Wa
Supplier: Cayman Chemical 173111 EA
A histamine H1 receptor antagonist (Ki 0.98 nM for the human receptor) selective for histamine H1 over H3 and H4 receptors (Kis 100 and 77.6 UM respectively for the human receptors) binds mAChRs (Ki 22 nM) inhibits histamine-induced paw edema and acetic acid-induced writhing in mice (ED50s 5.9 and 11.8 mg/kg respectively) decreases the number of motion-induced vomiting episodes in S. murinus at 32 mg/kg
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