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Genscript Corporation CTLA-4 Fc Chimera Mouse
Supplier: Genscript Corporation Z0339150
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 is an Inhibitory receptor acting as a major negative regulator of T-cell responses CTLA-4 is a member of the immunoglobulin superfamily which is expressed on the surface of T cells and transmits an inhibitory signal to T cells CTLA-4 and CD28 are homologous receptors expressed by both CD4 and CD8 T cells which mediate opposing functions in T-cell activation Both receptors share a pair of ligands expressed on the surface of antigen-presenting cells (APCs) The affinity of CTLA-4 for its natural B7 family ligands CD80 and CD86 is considerably stronger than the affinity of their cognate stimulatory co-receptor CD28
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