β-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.
- Theoretical MW (kDa): 111.9
- Preparation method: In vitro wheat germ expression system
- Purification: Glutathione Sepharose 4 fast flow
- Storage buffer: 50mM Tris-HCI, 10mM reduced Glutathione, pH=8.0 in the elution buffer
Best use within three months from the date of receipt of this protein.
Enzyme Linked Immunosorbent Assay, Western Blotting, Antibody Production, Protein Array
|50mM Tris HCl, 10mM reduced Glutathione, pH 8 in the Elution Buffer|
|Glutathione Sepharose 4 Fast Flow|
|Store at -80°C. Aliquot to avoid repeated freezing and thawing.|
|Antibody Production, Array, Enzyme-linked Immunoabsorbent Assay, Western Blot (Recombinant protein)|
|CTNNB1 (Human) Recombinant Protein (P01)|
|In vitro wheat germ expression system|
|12.5% SDS-PAGE Stained with Coomassie Blue.|
|Wheat Germ (in vitro)|
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