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ABclonal Technology CTRB1 Rabbit pAb
Supplier: ABclonal Technology A15043500UL
This gene encodes a serine protease that is a precursor of pancreatic proteolytic enzymes. The preproprotein is synthesized in the pancreas and secreted into the small intestine, where it is activated to form the functional enzyme. The CTRB1 gene is located head-to-head with the related CTRB2 gene. Some human populations have a haplotype with a 16.6 Kb inversion region, swapping portions of intron 1, exon 1, and upstream sequences between CTRB1 and CTRB2. This inversion is linked to differential gene expression and an increased risk of chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 in CTRB1. SNP rs8048956 in intron 1 of CTRB2 is diagnostic for the inversion. The CTRB1 gene encodes distinct isoforms, which may undergo similar processing to generate the mature protein.
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