Cayman Chemical CTX-0294885 25mg

Supplier:  Cayman Chemical 2219725 MG

A cysteine protease inhibitor inhibits human cathepsin S and cathepsin L (Kis 0 002 and 0 05 UM) and is selective for these proteases over human cathepsin K -B and -C (Kis 0 4 3 100 UM respectively) as well as SARS-CoV-2 PLpro and Mpro (Kis 100 UM for both) prevents cleavage of the spike protein S1 subunit in vitro and reduces the cytopathic effect of SARS-CoV-2 in infected Vero E6 HeLa/ACE2 and A549/ACE2 cells (EC50s T b brucei trypanosomes (IC50 0 1 UM) and reduces myocardial damage in a canine model of T cruzi infection at 50 mg/kg twice per day inhibits CCL17 binding to and CCL17-induced chemotaxis of HuT 78 cells (IC50s 0 057 and 0 0089 UM respectively)

Catalog No. 50-298-6344