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Apexbio Technology LLC CU CPT 4a 1279713-77-7 5mg
Supplier: Apexbio Technology LLC B57525
CU CPT 4a (CAS 1279713-77-7) is a small-molecule inhibitor that selectively targets Toll-like receptor 3 (TLR3) It disrupts TLR3-mediated signaling by blocking the interaction between TLR3 and double-stranded RNA (dsRNA) thereby suppressing downstream pathways In RAW 264 7 cells CU CPT 4a demonstrates an IC50 of 3 44 M for TLR3 inhibition and significantly reduces the production of pro-inflammatory cytokines including TNF- and IL-1 In murine models administration of CU CPT 4a has been shown to protect crypt cells from death and decrease the severity of radiation-induced gastrointestinal syndrome This compound is valuable for research into TLR3-related inflammatory and radiation injury mechanisms
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