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Medchemexpress LLC Cur61414 | 334998-36-6 | 99.0% | 550.69 | 50 MG
Supplier: Medchemexpress LLC HY11396550MG
CUR61414 is a novel, potent, and cell-permeable Hedgehog signaling pathway inhibitor with an IC50 of 100-200 nM. It is a small-molecule aminoproline class compound that selectively binds to smoothened (Smo) with a Ki value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.
- Novel, potent, and cell-permeable Hedgehog signaling pathway inhibitor.
- Selectively binds to smoothened (Smo).
- Induces apoptosis in cancer cells without affecting neighboring non-tumor cells.
- Able to arrest proliferation of basal cells within BCC-like lesions and induce apoptosis, leading to complete regression of lesions.
- Causes regression of BCC-like lesions in mice exposed to UV light irradiation, with no overt toxicity observed in surrounding skin.
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