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Enzo Life Sciences Curcumin (high purity) (10mg). CAS: 458-37-7
Supplier: Enzo Life Sciences ALX350028M010
Dual inhibitor of 5-lipoxygenase (IC50=8µM) and cyclooxygenase (COX) (IC50=52µM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Antioxidant. Inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), disrupting the binding of NQO1 to wild type p53 inducing ubiquitin-independent degradation of p53 and inhibits p53-mediated apoptosis in normal thymocytes and myeloid leukemic cells. Has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC50=10µM), the COP9 signalosome kinase (IC50=10µM) and p300/CBP. Alternative name: 1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane. Purity: ≥98% (HPLC). Appearance: Orange-yellow crystalline powder. Solubility: Soluble in acetic acid, 100% ethanol (at about 1mg/ml) or DMSO (25mg/ml). Long Term Storage: Ambient.
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