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Medchemexpress LLC CX-6258 hydrochloride | 1353859-00-3 | 99.0% | 498.40 | 50 MG
Supplier: Medchemexpress LLC HY18095A50MG
CX-6258 hydrochloride is a potent and kinase-selective pan-Pim kinases inhibitor, demonstrating IC50s of 5 nM for Pim-1, 25 nM for Pim-2, and 16 nM for Pim-3.
- Causes dose-dependent inhibition of the phosphorylation of pro-survival proteins, bad and 4e-bp1, at specific pim kinase sites.
- Treatment diminishes steady-state levels of ectopic nkx3.1 in pc3 cells.
- Treatment results in a significant reduction in nkx3.1 half-life.
- Exhibits robust in vivo efficacy in two pim kinase-driven tumor models.
- Demonstrates dose-dependent efficacy, producing 45% tumor growth inhibition at 50 mg/kg and 75% tumor growth inhibition at 100 mg/kg.
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