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Medchemexpress LLC CX-6258 (hydrochloride) | 1353859-00-3 | 99.0% | 498.40 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY18095B50MG

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CX-6258 hydrochloride is a potent and kinase-selective pan-Pim kinases inhibitor. It effectively inhibits Pim-1, Pim-2, and Pim-3, causing dose-dependent inhibition of pro-survival proteins like Bad and 4E-BP1. In vitro studies show it diminishes ectopic NKX3.1 levels, while in vivo, it exhibits robust efficacy in Pim kinases driven tumor models, demonstrating significant tumor growth inhibition.

  • Potent and kinase-selective pan-Pim kinases inhibitor.
  • Inhibits phosphorylation of pro-survival proteins.
  • Diminishes steady-state levels of ectopic NKX3.1 in PC3 cells.
  • Exhibits robust efficacy in Pim kinases driven tumor models in vivo.
  • For research use only.

Catalog No. 50-003-87331


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