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Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.2% | 516.42 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY18095A10MM/1ML

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CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively.

  • Potent and kinase selective pan-Pim kinases inhibitor
  • IC50s of 5 nM (Pim-1), 25 nM (Pim-2), 16 nM (Pim-3)
  • Causes dose-dependent inhibition of the phosphorylation of pro-survival proteins Bad and 4E-BP1 at specific Pim kinase sites (S112, S65, T37/46)
  • Diminishes steady-state levels and reduces half-life of ectopic NKX3.1 in PC3 cells
  • Exhibits robust in vivo efficacy in two Pim kinases driven tumor models (e.g., MV-4-11 xenograft models in nude mice)

Catalog No. 50-003-86875


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