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Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.2% | 516.42 | 25 MG
Supplier: Medchemexpress LLC 25MGHY18095A
CX-6258 hydrochloride hydrate is a potent and selective pan-Pim kinases inhibitor. It effectively inhibits Pim-1, Pim-2, and Pim-3, making it suitable for research into cancer and metabolic diseases.
- Potent and kinase selective pan-Pim kinases inhibitor
- Inhibits Pim-1 (IC50: 5 nM), Pim-2 (IC50: 25 nM), and Pim-3 (IC50: 16 nM)
- Causes dose-dependent inhibition of phosphorylation of pro-survival proteins, Bad and 4E-BP1
- Diminishes steady-state levels of ectopic NKX3.1 in PC3 cells
- Exhibits robust in vivo efficacy in Pim kinases driven tumor models
- Achieves 45% tumor growth inhibition at 50 mg/kg and 75% at 100 mg/kg in vivo
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