Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.23% | 516.42 | 100 MG

Supplier:  Medchemexpress LLC HY18095A100MG

CX-6258 hydrochloride hydrate is a potent and kinase-selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM, and 16 nM for Pim-1, Pim-2, and Pim-3, respectively. It is intended for research use only and not for sale to patients.

• Potent and kinase selective pan-Pim kinases inhibitor.
• Inhibits the phosphorylation of pro-survival proteins Bad and 4E-BP1 at specific Pim kinase sites (S112, S65, and T37/46 respectively).
• Diminishes steady-state levels of ectopic NKX3.1 in PC3 cells.
• Reduces NKX3.1 half-life.
• Exhibits robust in vivo efficacy in two Pim kinases driven tumor models, showing dose-dependent tumor growth inhibition (TGI) of 45% at 50 mg/kg and 75% at 100 mg/kg in MV-4-11 xenograft models in nude mice.

Catalog No. 50-003-86819