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Cayman Chemical CXCL974-103humntrIfl 10mg
Supplier: Cayman Chemical 3884910 MG
A CXCL9-derived peptide; binds to heparin in a cell-free assay (Kd = 3.1 nM); inhibits the binding of CXCL8 or CXCL11 to heparin, as well as CCL2 binding to heparan sulfate; reduces the cytopathogenic effect of RSV in HeLa cells, HSV-1 in HEL cells, and dengue virus serotype 2 in HMEC-1 cells (EC50s = 23, 15, and 11 µM, respectively); inhibits CXCL8 (1-77)- or monosodium urate-induced neutrophil extravasation to the tibiofemoral articulation in mouse models of acute inflammation or gout, respectively, at 100 UG/animal; increases survival and decreases liver neutrophil infiltration and necrosis in a mouse model of acetaminophen-induced liver injury; decreases BALF neutrophil infiltration and IL-1β levels, but does not reduce lung bacterial burden, in a mouse model of K. pneumoniae-induced pneumonia
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