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Medchemexpress LLC CXCR7 modulator 2 | 2227426-37-9 | 98.71% | 522.68 | 1 ML
SDP

Catalog No. 5000437959
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CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM. It is for research use only and not sold to patients. This modulator offers protection against cardiac injury.

  • Potent CXCR7-binding affinity (Ki=13 nM).
  • β-arrestin activity (EC50=11 nM).
  • Improved selectivity in the GPCR panel.
  • Improved therapeutic index in the hERG patch-clamp assay.
  • Moderate to high in vitro turnover in NADPH-supplemented mouse-liver microsomes (MLM, 93 μL/min/mg) and hepatocytes (28 μL/min per million cells).
  • Good aqueous solubility.
  • Rapidly absorbed with a mean maximal plasma concentration (Cmax) of 682 ng/mL at 0.25 h (Tmax).
  • Reduces cardiac fibrosis in an isoproterenol-induced cardiac injury model in mice.

Catalog No. 50-004-37959 Supplier Medchemexpress LLC Supplier No. HY11215410MM/1ML
May include imposed supplier surcharges.
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CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM. It is for research use only and not sold to patients. This modulator offers protection against cardiac injury.

  • Potent CXCR7-binding affinity (Ki=13 nM).
  • β-arrestin activity (EC50=11 nM).
  • Improved selectivity in the GPCR panel.
  • Improved therapeutic index in the hERG patch-clamp assay.
  • Moderate to high in vitro turnover in NADPH-supplemented mouse-liver microsomes (MLM, 93 μL/min/mg) and hepatocytes (28 μL/min per million cells).
  • Good aqueous solubility.
  • Rapidly absorbed with a mean maximal plasma concentration (Cmax) of 682 ng/mL at 0.25 h (Tmax).
  • Reduces cardiac fibrosis in an isoproterenol-induced cardiac injury model in mice.

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