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Medchemexpress LLC Cyclic ADP-ribose | 119340-53-3 | 500 UG
Supplier: Medchemexpress LLC HYN7395500UG
Cyclic ADP-ribose (cADPR) is a powerful second messenger involved in calcium mobilization. It is synthesized from NAD+ by an enzyme called ADP-ribosyl cyclase. cADPR primarily elevates cytosolic calcium levels through the Ryanodine receptor-mediated release of calcium from the endoplasmic reticulum, and also by facilitating extracellular calcium influx via the opening of TRPM2 channels.
- Potent second messenger for calcium mobilization
- Synthesized from NAD+ by ADP-ribosyl cyclase
- Increases cytosolic calcium via Ryanodine receptor-mediated release
- Facilitates extracellular calcium influx via TRPM2 channels
- Endogenous metabolite
- Purity of ≥96.0%
- Solid, white to off-white appearance
- Primarily intended for research purposes
- Used to study calcium release in various biological systems
- Investigated for its role in regulating oxytocin release
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