Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Cyclic Pifithrin-α hydrobromide 511296-88-1 25mg
Supplier: Apexbio Technology LLC A447725
Cyclic Pifithrin- hydrobromide (CAS 511296-88-1) is a synthetic small molecule that functions as an inhibitor of the tumor suppressor protein p53 By blocking p53-dependent transcriptional activation of response genes it interferes with p53-mediated cellular processes such as apoptosis and cell cycle arrest In vitro Cyclic Pifithrin- hydrobromide inhibits p53-dependent apoptosis and DNA damage-induced growth arrest in various cell models without notable effects on p53-deficient cells In vivo it protects mice from the toxic side effects of genotoxic cancer therapies likely through suppression of p53-dependent pathways This compound is utilized in research investigating p53 biology cellular stress responses and modulation of chemotherapeutic toxicity
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?