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Medchemexpress LLC Cyclo(CLLFVY) | 1446322-73-1 | 99.37% | 738.94 | 10 MG
SDP

Catalog No. 5000423823
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cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 values of 19 μM (in U2OS) and 16 μM (in MCF-7). It binds to the PAS-B domain of HIF-1α, thereby inhibiting HIF-1 dimerization and transcriptional activity. This compound also downregulates the expression of hypoxia response genes, such as VEGF and CAIX, demonstrating antitumor properties against HIF-1 associated cancers.

  • Inhibitor for hypoxia inducible factor-1 (HIF-1)
  • Binds to the PAS-B domain of HIF-1α
  • Inhibits HIF-1 dimerization and transcriptional activity
  • Downregulates the expression of hypoxia response genes (e.g., VEGF and CAIX)
  • Exhibits antitumor activity against HIF-1 associated cancers

Catalog No. 50-004-23823 Supplier Medchemexpress LLC Supplier No. HYP1042610MG
May include imposed supplier surcharges.
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cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 values of 19 μM (in U2OS) and 16 μM (in MCF-7). It binds to the PAS-B domain of HIF-1α, thereby inhibiting HIF-1 dimerization and transcriptional activity. This compound also downregulates the expression of hypoxia response genes, such as VEGF and CAIX, demonstrating antitumor properties against HIF-1 associated cancers.

  • Inhibitor for hypoxia inducible factor-1 (HIF-1)
  • Binds to the PAS-B domain of HIF-1α
  • Inhibits HIF-1 dimerization and transcriptional activity
  • Downregulates the expression of hypoxia response genes (e.g., VEGF and CAIX)
  • Exhibits antitumor activity against HIF-1 associated cancers

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