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Medchemexpress LLC Cyclo(L-cysteinyl-L-leucyl-L-leucyl-L-phenylalanyl-L-valyl-L-tyrosyl) | 1446322-73-1 | 99.37% | 738.94 | 5 MG
SDP

Catalog No. 5000423824
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Cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), demonstrating IC50 values of 19 μM in U2OS cells and 16 μM in MCF-7 cells. This compound functions by binding to the PAS-B domain of HIF-1α, thereby inhibiting HIF-1 dimerization and its transcriptional activity. It effectively downregulates the expression of hypoxia response genes, including VEGF and CAIX, and has shown antitumor effects against HIF-1 associated cancers.

  • Inhibitor for hypoxia inducible factor-1 (HIF-1)
  • Binds to the PAS-B domain of HIF-1α
  • Inhibits HIF-1 dimerization and transcriptional activity
  • Downregulates expression of hypoxia response genes (VEGF, CAIX)
  • Exhibits antitumor effects against HIF-1 associated cancers
  • Appearance: White to off-white solid
  • Solubility: 100 mg/mL in DMSO
  • Long-term storage: -80°C for powder

Catalog No. 50-004-23824 Supplier Medchemexpress LLC Supplier No. HYP104265MG
May include imposed supplier surcharges.
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Cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), demonstrating IC50 values of 19 μM in U2OS cells and 16 μM in MCF-7 cells. This compound functions by binding to the PAS-B domain of HIF-1α, thereby inhibiting HIF-1 dimerization and its transcriptional activity. It effectively downregulates the expression of hypoxia response genes, including VEGF and CAIX, and has shown antitumor effects against HIF-1 associated cancers.

  • Inhibitor for hypoxia inducible factor-1 (HIF-1)
  • Binds to the PAS-B domain of HIF-1α
  • Inhibits HIF-1 dimerization and transcriptional activity
  • Downregulates expression of hypoxia response genes (VEGF, CAIX)
  • Exhibits antitumor effects against HIF-1 associated cancers
  • Appearance: White to off-white solid
  • Solubility: 100 mg/mL in DMSO
  • Long-term storage: -80°C for powder

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