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Medchemexpress LLC Cyclo(RLsKDK) TFA | 99.7% | 841.88 | 1 MG
SDP

Supplier:  Medchemexpress LLC HYP1676A1MG

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Cyclo(RLsKDK) TFA is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. It is utilized in research for inflammatory diseases and cancer studies.

  • Specific inhibitor of metalloproteinase ADAM8 (IC50 182 nM).
  • Promotes ADAM8 activation and CD23 shedding (IC50 120 nM and 182 nM).
  • Increases activity of pro-ADAM8.
  • Reduces tumor load and improves survival rates in pancreatic ductal adenocarcinoma (PDAC) mice models.
  • Reduces sADAM8 content, pERK1/2 activation, and PDAC metastasis in vivo.

Catalog No. 50-004-23667


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