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Medchemexpress LLC Cycloguanil (hydrochloride) | 152-53-4 | >99.9% | 10 MG
Supplier: Medchemexpress LLC HY12784A10MG
Cycloguanil (hydrochloride) is a dihydrofolate reductase (DHFR) inhibitor, effective against human DHFR with an IC50 of 10.8 μM. It interferes with DNA replication by blocking the folate metabolic pathway, thereby affecting nucleotide synthesis. This compound is utilized in malaria research due to its ability to inhibit DHFR in *Plasmodium*, and also demonstrates anticancer activity by potently inhibiting DHFR in human cancer cells and blocking the transcriptional activity of STAT3.
- Blocks folate metabolic pathway
- Affects nucleotide synthesis and DNA replication
- Used in malaria research by inhibiting DHFR in *Plasmodium*
- Potently inhibits DHFR in human cancer cells
- Blocks transcriptional activity of STAT3, exhibiting anticancer activity
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