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Medchemexpress LLC Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride (1:1) | 75136-54-8 | 99.9% | 353.88 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY18100A100MG

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PRE-084 hydrochloride is a highly selective sigma 1 receptor (S1R) agonist (IC50 of 44 nM). It exhibits neuroprotective effects, improves motor function and motor neuron survival, and ameliorates myocardial ischemia-reperfusion injury by activating the Akt-eNOS pathway. This product is for research use only.

  • Protects cultured cortical neurons against β-amyloid toxicity and reduces proapoptotic protein Bax.
  • Improves motor performance, neuron survival, paw abnormality, and grip strength in mice.
  • Increases BDNF levels and modifies glial cell populations.
  • Protects heart by activating Akt-eNOS pathway, decreasing myocardial apoptosis.
  • Increases expression of p-Akt and p-eNOS.
  • Appears as a white to off-white solid.
  • Store at 4°C sealed, away from moisture; in solvent at -80°C for 6 months or -20°C for 1 month.

Catalog No. 50-003-87210


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