Cyclopamine, 99%

Catalog No.	Quantity
AAJ61528MB	25 mg
AAJ61528MF	50 mg

Catalog No. AAJ61528MB Supplier Thermo Scientific Chemicals Supplier No. J61528MB

Description

CAS: 4449-51-8 | C27H41NO2 | 411.63 g/mol

Cyclopamine, is used as a hedgehog [Hh] signaling pathway and Smo inhibitor. It depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Cyclopamine, is used as a hedgehog [Hh] signaling pathway and Smo inhibitor. It depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

Solubility
Soluble in ethanol (5 mg/ml warm), DMSO (4 mg/ml), DMF (10 mg/ml), methylene chloride, chloroform, methanol (7 mg/ml), and benzene.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 4449-51-8
• Molecular Formula: C27H41NO2
• Molecular Weight (g/mol): 411.63
• MDL Number: MFCD01735266
• InChI Key: QASFUMOKHFSJGL-LAFRSMQTSA-N
• Synonym: cyclopamine, 3b,23b-17,23-epoxy-11-deoxoveratraman-3-ol
• PubChem CID: 122130428
• SMILES: C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C

• Melting Point: 234°C to 237°C
• Color: White
• Quantity: 25 mg
• Solubility Information: Soluble in ethanol (5mg/ml warm),DMSO (4mg/ml),DMF (10mg/ml),methylene chloride,chloroform,methanol (7mg/ml),and benzene.
• IUPAC Name: (3S,3'R,3'aS,6'S,6aS,9S)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
• Formula Weight: 411.62
• Percent Purity: ≥99%
• Physical Form: Powder
• Chemical Name or Material: Cyclopamine

Safety and Handling

Hazard Category	H341-H361
Hazard Statement	GHS H Statement H341-H361 Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child.
Precautionary Statement	P201-P202-P281-P308+P313-P501c
RTECSNumber	GY0750000
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only