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Apexbio Technology LLC Cyclophosphamide monohydrate 6055-19-2 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A42325.1
Cyclophosphamide monohydrate is an alkylating cytotoxic agent exhibiting antitumor activity primarily via metabolic activation As a prodrug it undergoes hepatic biotransformation mediated by cytochrome P450 enzymes forming active alkylating metabolites such as 4-hydroxycyclophosphamide which exert cytotoxic effects through interactions with cellular DNA Cyclophosphamide also reversibly inhibits acetylcholinesterase (AChE) displaying an IC50 of approximately 511 M It is widely utilized in experimental cancer studies particularly in pediatric oncology where alterations in drug metabolism or drug-drug interactions impacting cyclophosphamide clearance and therapeutic outcomes have been explored
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