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Cayman Chemical CyclopIazonIc AcId-13C20 1.2mL

Supplier: Cayman Chemical 312971.2 ML

An a1-AR antagonist and partial 5-HT1A agonist selectively binds to a1- over a2-ARs (IC50s 0 74 and 42 M respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s 0 4 20 4 and 10 M respectively) in rat cortex inhibits forskolin-induced cAMP accumulation in calf hippocampus as a functional model for 5-HT1A receptors (EC50 390 nM) inhibits the isoproterenol-induced positive chronotroptic response in isolated rat atria (pA2 6 05) lowers MAP in anesthetized cats at 1 mol/kg i v
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