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Medchemexpress LLC Cyclosporin A-13C2,d4 | 59865-13-3 | 95.2% | 500 UG
Supplier: Medchemexpress LLC HYB0579S3500UG
Cyclosporin A-13C2,d4 is a 13C labeled Cyclosporin A. This immunosuppressant binds to cyclophilin and inhibits the phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM. It also inhibits CD11a/CD18 adhesion. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules for quantitation during drug development.
- Functions as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration may affect pharmacokinetic and metabolic profiles of drugs
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