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Apexbio Technology LLC Cyclosporin A 59865-13-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B19225.1
Cyclosporin A is an immunosuppressive agent acting primarily through inhibition of cyclophilins intracellular peptidyl-prolyl isomerases with a reported IC50 of 7 nM Cyclophilins regulate mitochondrial permeability transition pore (MPTP) opening intracellular calcium signaling and NFAT transcriptional activation pathways Cyclosporin A s ability to inhibit calcineurin-NFAT signaling in T-cell activation leads to suppression of inflammatory immune responses indicating potential use in autoimmune disorder research Additionally it modulates cell apoptosis and survival mechanisms in diverse models including retinal ischemic injury viral entry (HBV HCV) and tumor biology in colon cancer cell lines
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