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Enzo Life Sciences Cyclosporin A (500mg). CAS: 59865-13-3
Supplier: Enzo Life Sciences BMLA1950500
Cyclosporin A (CsA) is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. CsA binds to cyclophilin and suppresses its proline rotamase activity. The CsA-cyclophilin complex inhibits calcineurin, a type 2B phosphatase. It is an important diagnostic tool for the characterization of permeability transition-related phenomena. It inhibits mitochondrial permeability transition pore opening however, pore inhibition becomes less efficient at increasing Ca2+ loads and inhibition is transient. Inhibits staurosporin-induced apoptosis in cultured neural cells and rotenone-induced apoptosis in PC-12 cells. Inhibits cytochrome c release from mitochondria. Inhibits nitric oxide (NO) synthesis. Alternative name: CsA. Purity: ≥98% (Assay). Solubility: Soluble in DMSO (25mg/ml), methanol, 100% ethanol (25mg/ml), acetone or petroleum ether; insoluble in water. Long Term Storage: -20°C.
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