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ACROBiosystems Cynomolgus / Rhesus B7-H4, His Tag (B74-C52H9) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Ala 258 (Accession # F7B770-1).

Supplier:  ACROBiosystems B74C52H9100UG

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V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

Catalog No. 50-225-3118


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