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Cayman Chemical CysteInyl LeukotrIen AChE Tr
Supplier: Cayman Chemical 400390500 DTN
A JAK2 inhibitor (IC50 3.9 nM) selective for JAK2 over JAK3 (IC50s 70 nM) as well as Aurora B kinase VEGFR2 Abl1 and GSK3B (IC50s 0.441 1.5 21.37 and 50 UM respectively) but does inhibit JAK1 and TYK2 (IC50s 7 and 2.9 nM respectively) inhibits STAT3-mediated transcription of IL6 in a SEAP reporter assay (IC50 162 nM) reduces ocular inflammation as well as decreases Il6 expression in the meibomian glands in a mouse model of allergic eye disease at 1 and 3 mg/ml
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