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Apexbio Technology LLC Cytarabine(Synonyms: Ara-C, Cytosine arabinoside, Arabinosylcytosine, Cytosar-U, Cytosar, Depocyt), 200mg, CAS: 147-94-4.
Supplier: Apexbio Technology LLC A8405200
Cytarabine (CAS 147-94-4) also known as AraC is a nucleoside analog structurally related to deoxycytidine It acts primarily by incorporation into DNA subsequently hindering DNA synthesis via inhibition of DNA and RNA polymerases AraC requires phosphorylation by deoxycytidine kinase (dCK) to its active monophosphate metabolite Reduced dCK activity or expression of alternatively spliced inactive dCK isoforms has been linked to resistance in leukemic cell lines Additionally cytarabine induces apoptosis and inhibits cell proliferation involving p53 stabilization independent of transcriptional elevation as demonstrated in rat trophoblast cells Clinically cytarabine remains extensively studied in leukemia models and cellular apoptosis pathways
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