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Apexbio Technology LLC Cytarabine hydrochloride 69-74-9 200mg
Supplier: Apexbio Technology LLC B1100200
Cytarabine hydrochloride (69-74-9) is a small-molecule nucleoside analog designed to inhibit DNA synthesis thereby disrupting nucleic acid replication in target cells Cytarabine hydrochloride exerts its biological activity primarily through intracellular phosphorylation to its active triphosphate form which competes with dCTP and incorporates into DNA leading to inhibition of DNA polymerase activity In cell-based studies Cytarabine hydrochloride demonstrates inhibitory activity with an IC50 value of approximately 16 nM in the CCRF-CEM cell line 103 M in CEM/AraC8C and 223 M in CEM/dCK Additional WST-1 viability assays in KA leukemic cells report IC50 values of 0 69 M (KA) 1 73 M (KA/GFP) and 0 037 M (KA/wt) Based on these pharmacological properties Cytarabine hydrochloride holds research potential in leukemia mechanism and sensitivity studies
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